On the other hand, we previously reported that KRAS-mutated CRC could facilitate another pathway of aspartate metabolism, wherein the cancer cells could become adaptive to glutamine depletion by upregulating the expression of asparagine synthetase (ASNS), an enzyme that synthesizes asparagine from aspartate, thereby avoiding nutrient stress-induced apoptosis [25]. This evidence concerns the gene ASNS and colorectal carcinoma.