It has been proposed that the labdane diterpene forskolin inhibits the increase in monocyte chemotactic protein-1 (MCP-1) mRNA levels and the decrease in G-protein coupled receptor 120 (GPR120) mRNA levels in adipocytes upon LPS induction, making a potential therapeutic agent for the treatment of inflammation in obesity [73]. The gene discussed is CCL2; the disease is obesity due to melanocortin 4 receptor deficiency.