Besides, IL-33 induced a direct tumor-killing effect by enhancing the expression of effector molecules, including degranulation markers (CD63 and CD107a), activators (CD69), adhesion molecules (CD11b/CD18 and ICAM-1), cytokines (TNF-α), and effector molecules (granzyme A) [85,86,87]. The gene discussed is IL33; the disease is neoplasm.