In addition, the inhibitory effects of adiponectin on the proliferation and invasion of lung cancer cells is mediated by an alteration of cell cycle kinetics by inhibiting CREB [103], reducing the activation of inflammatory pathways through the NF-κB-AdipoR1 pathway, and increasing the levels of anti-inflammatory cytokines such as IL-10 [104]. This evidence concerns the gene NFKB1 and lung carcinoma.