Although anti-DNMT3A autoantibody were found elevated in the LC compared to the HCC group, however, no significant differences were found between HCC and NHS groups in anti-DNMT3A or HSP60 autoantibodies, suggesting that these two autoantibodies might not be applicable for Asian HCC diagnosis, and they might be the exclusive diagnostic biomarkers for Hispanic HCC. Here, DNMT3A is linked to hepatocellular carcinoma.