Regarding AD, clinical studies showed that significantly higher serum MMP-8 levels were detected in acute AD patients than in control subjects [49], that a prominent increase in plasma MMP8 level was reported in the acute phase of AD [50], and that combination of plasma MMP8 and D-dimer at individually suboptimal cutoffs could provide a better diagnostic value for acute AD under medical emergency [51]. The gene discussed is MMP8; the disease is Alzheimer disease.