PPARG and colonic neoplasm: Strikingly, Zhong et al. have illustrated the potentiality of natural flavonoid modulator, apigenin, in activating PPAR-γ by inducing apoptosis with cell cycle arrest at the G2/M phase in HCT-116, SW480, HT-29 and LoVo colon cancer cells, thereby upregulating pro-apoptotic proteins (NAG-1 and p53) and cell cycle inhibitor (p21) [90].