Treatment of both healthy and periodontally diseased gingival fibroblasts with pan-HDACi or HDAC3/6i prior to P. gingivalis infection significantly reduced the induction of a subset of inflammatory mediators (CCL2, CCL5, CXCL10, IL1B, COX2 and MMP3) implicated in periodontitis [58]. This evidence concerns the gene PTGS2 and periodontitis.