PCNA and precursor B-cell acute lymphoblastic leukemia: Additionally, PCNA plays an important role in cancer because it is overexpressed in multiple cancer types, including non-small cell lung cancer [45], hepatocellular carcinoma [46], breast cancer [47], and pancreatic cancer [48], as well as in our present B-ALL results, suggesting that PCNA overexpression is a potential marker for many cancer types.