Besides the “classical” neurotrophic factors, there are growth factors with neurotrophic effects and newly classified NTFs, such as vascular endothelial growth factor (VEGF) and neurotrophic factor-α1 (NF-α1, also known as carboxypeptidase E or CPE), that have also been linked to AD [32,33]. This evidence concerns the gene CPE and Alzheimer disease.