MMP14 and cancer: Because of the elevated MMP-14 expression observed in breast [32,33], head and neck [33], fibrosarcoma [33,34], prostate [34], gastric [35], bladder [36], ovarian [37] and brain [38] cancer, the detection and measurement of MMP-14 has an essential role in the diagnostic and the treatment direction of cancer The catalytic domain is usually the target domain for the electrochemical detection of MMPs because of communication between the redox active center (zinc) and the electrode surface.