MAPT and tauopathy: To uncover the pathogenic pathway and identify therapeutic interventions of Chinese herbal medicines in Tau-induced toxicity, we modeled tauopathy in the notum of Drosophila melanogaster. However, given that the p-Tau protein in Drosophilamelanogaster occurs at extremely low levels and is difficult to detect precisely, we used IMR technology that included the use of antibody-functionalized magnetic nanoparticles and a high-Tc SQUID-based ac magnetosusceptometer.