In view of AD biomarkers such as Aβ and p-Tau protein in Drosophilamelanogaster, which occur at extremely low levels and are difficult to detect precisely, IMR was applied in this study, which has been successfully developed to detect extremely small amounts of p-Tau protein in the cerebrospinal fluid of human [11,12,13,14]. The gene discussed is MAPT; the disease is Alzheimer disease.