These two hallmark genes of pancreatic cancer serve as a basis for our choice of, PANC1 (p53/KRAS double mutant), CAPAN2 (p53-WT/KRAS-mut), and BXPC3 (p53-mut/KRAS-WT) as robust in vitro models of PDAC. Here, KRAS is linked to pancreatic neoplasm.