CTLA4 and toxicity: This study’s reported incidence of long-term or permanent irAEs is lower than that of our study, particularly with regard to skin toxicity; there are multiple potential reasons for this, including the fact that our study included patients who had received different ICI regimens such as combined anti-CTLA-4/anti-PD-1 therapy, which is known to be more toxic, and patients who had received multiple ICIs across multiple lines of therapy.