In addition, in recent years, we have witnessed an increasing interest in the targeting of molecular pathways involved in CCA tumorigenesis, and several targets of interest have been identified, including—among others—isocitrate dehydrogenase-1 (IDH-1), fibroblast growth factor receptor 2 (FGFR2), human epidermal growth factor receptor 2 (HER2), high microsatellite instability (MSI-H), and neurotrophic tropomyosin receptor kinase (NTRK) [11,12,13,14,15,16,17]. The gene discussed is FGFR2; the disease is cholangiocarcinoma.