The groups were equally distributed for BMI with almost half (51% TP53 PV carriers and 52% relatives) being normal or underweighted (BMI < 25 kg/m2), followed by a third meeting the criteria of pre-obesity (29% and 31% for BMI 25–<30 kg/m2), 12% and 10% for obesity class I (BMI 30–<35 kg/m2), 6% and 2% for class II (BMI 35–<40 kg/m2), 3% and 5% for class III (BMI > 40 kg/m2), respectively. Here, TP53 is linked to obesity due to melanocortin 4 receptor deficiency.