In previous studies, mutations additional to JAKV 617F have been frequently reported in PV patients (53–78%) in a variety of genes, with maximum frequency observed in the TET2 (22–30%) gene, followed by ASXL1(10 to 12%) and DNMT3A gene (13%) [32,33,34]. The gene discussed is DNMT3A; the disease is acquired polycythemia vera.