Interestingly, we further found that high expression of FOXO1 had higher ratio of CD3 (IFNƳ), Th1, CD8T and CD8T (Tc1) as when compared to those with low expression, suggesting that FOXO1 gene was closely related to expansion of number of immune cells and cell polarization in MDS. This evidence concerns the gene FOXO1 and myelodysplastic syndrome.