IDH1 and central nervous system cancer: According to histogram analysis, IDH-mutated gliomas had remarkably lower mean (0.93 ± 0.44 vs. 1.39 ± 0.49; p = 0.03) and 50th percentile (0.96 ± 0.36 vs. 1.39 ± 0.46; p = 0.02) APT values than IDH-wildtype gliomas [74] (Table 2).