Conversely, Wang et al. indicated that in the mutant IDH1 group, the absence of edema predicted longer OS (p = 0.032) and PFS (p = 0.024), and there were no remarkable differences in edema between glioma patients with mutant (13/45, 28.9%) and IDH1-wildtype (54/235, 23.0%) (p = 0.395, chi-square test) [34] (Table 1). Here, IDH1 is linked to central nervous system cancer.