PIK3CA and neoplasm: In a study including 97 TNBC and 36 non-TNBC tumour samples, IHC and formalin-fixed paraffin-embedded (FFPE) samples show 33% of TNBC have malfunctioning PI3K/Akt pathways; with overexpression of Akt and p-p44/42 MAPK proteins in all the samples bearing PIK3CA mutation [36,37].