PTEN and miotic rate: Higher losses of phosphatase and tensin homolog (PTEN), retinoblastoma (RB1), and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) expressions, along with beclin-1 (BECN1) mutation that causes MR by impairing autophagy, are particularly reported in TNBC [19].