CXCR4 and colorectal carcinoma: In addition, the stimulation of fermented NaDES-ginger extract on HCT-116/R cells dramatically decreased the expression of CXCR4 (Figure 5), while the siRNA-mediated inhibition of CXCR4 gene expression would further enhance the lethal effect of fermented NaDES-ginger extract on CRC cells (Figure 6).