Betulinic acid acts as an FXR that attenuates the formation of HFD and MCD-induced NAFLD, and it has been confirmed that Allisma orientalis stimulates FXR activation, especially allisol A24B-acet action, thereby restoring hepatocellular ER homeostasis [148]. The gene discussed is NR1H4; the disease is metabolic dysfunction-associated steatotic liver disease.