NAFLD is influenced by the environment, the intestinal microbiota, and an abnormal glucose-lipid ratio, metabolic pathways, metabolic inflammation predominantly driven by innate immunological signaling, adipocytokine dysfunction (e.g., tumor necrosis factor (TNF)-α, adiponectin, resistin, and adiponectin) are all associated with metabolic syndrome, leptin, angiotensin II, and coexisting [77,78,79]. This evidence concerns the gene ADIPOQ and metabolic dysfunction-associated steatotic liver disease.