An in vitro study carried out by Antonella Leone and coauthors [116] showed that grape seed extracts induce apoptotic cell death in MCF-7 breast cancer cells, which is mediated by improving gap-junction-mediated cell-cell communications through reallocating connexin-43 (cx43) proteins on plasma membranes and controlling cx43 mRNA expression [116]. This evidence concerns the gene GJA1 and breast carcinoma.