LDLR and hyperlipidemia: Low-density lipoprotein receptor knockout (LDLR KO) mice, frequently used in atherosclerosis investigations, are deficient in LDL receptor which impairs the rate of very low-density lipoprotein (VLDL) and LDL removal from the plasma; thus, favoring hyperlipidemia and moderate vascular lesions (atherogenesis) even when fed a normal low-fat rodent chow [4].