In conclusion, our findings reveal that AET counteracts the deleterious effects of chronic LS diet in atherogenesis by reducing peripheral IR, lipid infiltration, CML, RAGE, 4-HNE, and AT1 receptor in the intima-media of the brachiocephalic trunk in LDLR KO mice. The gene discussed is AGER; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.