PTGS2 and Hyperglycemia: The repression of NEAT1 can exert a protective role from the hyperglycemia-induced oxidative stress and inflammation by increasing superoxide dismutase activity, reducing the levels of ROS and malondialdehyde [88], and repressing inflammatory cytokines, such as the cyclooxygenase 2 (COX-2), IL-6 and TNF-α [88].