AKT1 and diabetes mellitus: Interestingly, MIAT knockdown inhibits tube formation, migration, and proliferation in endothelial cells, and ameliorates diabetic retinal microvascular dysfunctions in vivo, also reducing apoptosis through a partial modulation of the caspase-3 expression and phosphorylation of Akt serine/threonine kinase 1 (Akt1) [59].