The investigation of medulloblastoma (MB)—a primitive neuroectodermal tumor—cell lines (D341, DAOY, and D283) and two HGG cell lines, T-98-G and U-87MG, revealed that 2-ME treatment induces apoptosis via phosphorylation of cdc25C regulatory proteins and the activation of caspase 3. The gene discussed is CASP3; the disease is neoplasm.