For glioblastoma multiforme (GMB), three key signaling pathways have been recognized as the most unregulated in glioblastoma, notably RTK/Ras/phosphoinositide 3-kinase (PI3K) pathway activation and the suppression of the p53 protein and retinoblastoma protein (Rb) [61]. The gene discussed is TP53; the disease is glioblastoma.