Corroborating the role of HO-1 as oncoprotein, in colon cancer cells the glucose-regulated protein 78 (GRP78) enhances migration and invasiveness by inducing vimentin expression, in turn reducing E-cadherin level, and triggering Nrf2/HO-1 signaling [39]. This evidence concerns the gene HMOX1 and malignant colon neoplasm.