HMOX1 and neoplasm: On the other hand, metastatic disease patients presented a neoplasm characterized by a greater median largest diameter (15.4 mm versus 13.3 mm, p = 0.102), and a higher median HO-1 expression (8 versus 2, p < 0.001 and shorter median disease-free survival (24 months versus 86 months, p < 0.001) (Table 3).