It is known that, in obese patients and obese rodent models, adipose tissues express high levels of TNF-α [84], and over-express other proinflammatory cytokines such as lipopolysaccharide (LPS), interferon-gamma (IFN-γ), TNF-α, interleukin-1beta (IL-1ß), interleukin-12 (IL-12) and IL-6 associated with insulin resistance that allow for the recruitment of macrophages and other types of leukocytes [85,86]. The gene discussed is IFNG; the disease is Insulin resistance.