NFE2L2 and metabolic dysfunction-associated steatohepatitis: We developed p62/sequestosome 1 (p62) and nuclear-factor-erythroid-2-related factor 2 (Nrf2) double knockout mice (DKO); male DKO mice spontaneously developed adult-onset NASH and its associated hepatocarcinogenesis following normal chow (NC) feeding [33], exhibiting a phenotype similar to human NASH [33].