BAK1 and hepatocellular carcinoma: Alpinumisoflavone-treated Huh7 and Hep3B cells showed a remarkable decrease in the expression levels of anti-apoptotic protein Bcl-xL phosphorylation (Figure 7C), while the expression levels of pro-apoptotic protein BAK increased in proportion to that of alpinumisoflavone concentration up to a 1.3-fold change in both the HCC cell lines (Figure 7D).