NFE2L2 and ischemia: Second, and strictly related to the previous statement, a proper Nrf2 functioning is relevant for endothelial homeostasis and vasoprotection; the evidence from several studies strongly suggests that Nrf2 alteration in endothelial cells is associated with ageing and various age-related pathologies, such as ischemia, cardiovascular diseases, and DR [23,48,49,50].