Inhibited Nrf2/NQO1/HO1 expression in endometrial cancer cellsSuppressed Nrf2-ARE activity when combined with cisplatinEnhanced early apoptosis when combined with cisplatinInhibited Tet1 expression/Tet1-induced hydroxymethylation Enhanced the inhibitory effect of cisplatin on migration and invasion. Here, HMOX1 is linked to endometrial cancer.