Furthermore, stigmasterol activated pro-apoptotic proteins, triggered PI3K/Akt, Akt/mTOR, and JAK/STAT, VEGFR-2 signaling pathways involved in numerous types of cancers and suppressed chemoresistance and enhanced inhibitory activity of some antiproliferative drugs [33,34,35,36,37,38]. The gene discussed is AKT1; the disease is cancer.