COPS5 and gallbladder cancer: Concerning the exploration of the anti-tumor effect of stigmasterol against Jab1 in gallbladder cancer cells, Pandey et al. [92] in their investigation clearly showed that this compound induces gene modulations via the down-regulation of the Jab1 gene and the up-regulation of p27 expression that could be produced by the mitochondrial apoptosis signaling pathway.