It was recently reported that thioredoxin (TRX)-interacting protein (TXNIP) may have a negative association with TRX, and the decreased SOD activities and increased malondialdehyde levels resulting in the upregulation of ROS and oxidative stress in nasal epithelial cells may play a pivotal role in the pathogenesis of CRSwNP [40]. The gene discussed is TXN; the disease is chronic rhinosinusitis with nasal polyps.