Prdx6 upregulation has been reported as a defensive compensatory reaction to the oxidative damage in patients and animal models of Parkinson’s disease, Alzheimer’s disease, Pick’s disease, amyotrophic lateral sclerosis, glioma, and traumatic brain injury [23,27,29,43,44,45]. The gene discussed is PRDX6; the disease is early-onset autosomal dominant Alzheimer disease.