Treatment with KH (19.11 ± 0.23 U/mg prot), combined KH + metformin (20.12 ± 0.26 U/mg prot), and combined KH + clomiphene (19.79 ± 0.28 U/mg prot) significantly increased the total SOD activities (p < 0.05) compared with the untreated PCOS rats (11.97 ± 0.12 U/mg prot). This evidence concerns the gene SOD1 and polycystic ovary syndrome.