Women with normal-weight pregnancies have decreased insulin sensitivity, increased protein synthesis, and increased lipogenesis and fat accretion, while obese pregnant women are more likely to develop gestational diabetes [75] and to have increased elevations in pro-inflammatory cytokines, glucose, lipids, and amino acids [76,77], exposing the growing placenta and fetus to a mix of inflammatory cytokines and excess nutrition in utero, which may have long-lasting effects on postnatal life. This evidence concerns the gene INS and gestational diabetes.