IFNG and leukemia: Zinc sufficiency (15 μM-50 μM zinc) increased IFN-γ in HUT-78 cells (human malignant leukemia cells) by up-regulating gene expression of T-bet [65], a master transcription factor for the expression of T helper 1-producing cytokines such as IFN-γ, IL-2, and TNF-α/β.