The deficiency of specific proteins can lead to specific diseases; for example, XPA, XPB, XPC, XPD, XPE, XPF and XPG are derived from xeroderma pigmentosum and belong to the GG-NER sub-pathway, while CSA and CSB proteins are associated with Cockayne syndrome, which belongs to the TC-NER sub-pathway. This evidence concerns the gene ERCC5 and xeroderma pigmentosum.