ACE2 and infection: Other studies corroborate this finding [27,28,46] when investigating other SARS-CoV-2 variants such as Alpha, Gamma, and Delta, pointing out that male patients may have a greater expression of the ACE2 enzyme, which is regulated by male sex hormones, making this group of people more susceptible to infections and more severe SARS-CoV-2 cases [28,50].