In the study of Cristofolini et al., caffeic acid-magnetic calcium phosphate (CAF-MCAP) nanoparticles with multifunctional magnetic nanostructure SPION were coated with caffeic acid and stabilized by layers of CaP and PEG-polyanion, for incorporation of siRNA to target breast cancer cells HER2 gene [103] (Figure 5D). This evidence concerns the gene ERBB2 and breast carcinoma.