Because no significant associations between the rs3025020 genotype and HTLV-1 infection were observed, the lack of angiogenesis-related hetero-cellular communication and shortage of VEGF-related tumor-induced immune suppression might play important roles in the inverse association between being an rs3025039 (T) allele carrier and HTLV-1 infection. The gene discussed is VEGFA; the disease is neoplasm.