Within genotyping to reveal an increased risk of immune reactivity associated with rapid progression of periodontitis, patients H1, H2, H3, H8, H9 and H10 were found to have a positive genotype within the polymorphism in the genes IL1-A (rs1800587), IL1-B (rs1143634) and IL-1RN (rs419598). The gene discussed is IL1B; the disease is periodontitis.