Whereas mutated TTR causes hereditary transthyretin amyloidosis ATTRv, a rare disease with a devastating outcome, native non-mutated TTR can nevertheless undergo spontaneous aggregation that results in a predominant cardiac phenotype of wild type ATTR cardiac amyloidosis with consequent heart failure that tends to co-occur with neural involvement in many cases [4]. The gene discussed is TTR; the disease is cardiac amyloidosis.