Add to this RS increases, in viral infections have been found the inhibition of pathways mediated by the nuclear factor erythroid related factor 2 (Nrf2), which is a master transcription regulator of genes related to antioxidant enzymes necessaries to counteract the increases of O2− and H2O2 (superoxide dismutases (SODs), glutathione peroxidases (GPXs), and catalase (CAT)) [57,58]. Here, NFE2L2 is linked to viral infectious disease.