IL1B and periodontitis: In vivo mechanistic studies in mice revealed that the senescence biomarkers beta galactosidase (SA-β-Gal), p16, p21, IL6, TNFα and IL1β expression were elevated in aged and periodontitis, and that bone marrow-like CD11c+ and T cells were prone to senescence in vivo, with Pg-induced EXO of DCs being the main causative agent of alveolar bone loss and immune senescence.