RELN and colitis: Figure 6B shows that p53 mRNA abundance follows a pattern similar to that of the p53 protein, with the exception of DSS-untreated reeler mice: p53 mRNA does not decrease as the protein does. Altogether, the data indicate that reelin is required for p53 transcription and activation through phosphorylation-Ser15 and that acute colon inflammation increases p53 transcription and activation.