The results exhibited that, except for the increased expression of E-cadherin, the EMT markers (N-cadherin and Vimentin) and the stemness markers (SOX2, BMI1 and OCT4) in Hep-G2 and HCC-LM3 cells were declined by genistein and miR-1275 mimic (Figure 3E). This evidence concerns the gene POU5F1 and hepatocellular carcinoma.