Although the Croatian guidelines advocate that bacterial infection is likely in case of leukocytosis and/or a neutrophil left shift with increased procalcitonin concentration and very high CRP and IL-6 levels, elevated procalcitonin and IL-6 levels have low positive predictive value for bacterial infection in the COVID-19 setting and are also observed in the context of COVID-19 sepsis. This evidence concerns the gene CRP and COVID-19.