Neutrophil gelatinase-associated lipocalin, insulin-like growth factor-binding protein 7, and tissue inhibitor of metalloproteinases-2 have been identified in serum and urine as biomarkers with significant AKI prediction abilities in patients who are critically ill, septic, undergoing cardiac surgery, experience trauma, or have diagnosed contrast nephropathy [13,157,158,159,160]. The gene discussed is IGFBP7; the disease is acute kidney injury.