Activation of the ROS-NF-kB pathway triggers the production of various inflammation cytokines such as IL-6, TNF-α, vascular endothelial growth factor (VEGF), intercellular cell adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), IL-1b, and IL-33, as well as some other factors that display a pivotal role in the alteration of the tumor immune-suppressive microenvironment [162]. The gene discussed is VCAM1; the disease is neoplasm.